By Philippe Derreumaux
Alzheimer's sickness is the commonest type of senile dementia, affecting greater than 24 million humans all over the world. it's characterized pathologically by means of abnormally excessive degrees of neurofibrillary tangles because of the buildup of tau protein in lifeless and demise neurons, and via increased numbers of senile plaques within the cortex and hippocampus of the mind. the most important part of senile plaques is a small protein of 39–43 amino acids known as amyloid-β (Aβ). to date, no therapy has been proven to gradual the development of sporadic and familial Alzheimer's disease.
A huge physique of proof issues, even if, to the early Aβ-formed oligomers because the basic poisonous species in Alzheimer's sickness. a strong procedure for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and make sure the buildings of the poisonous aggregates.
This publication offers a wide ranging view throughout fresh in vitro and in vivo stories in addition to state of the art laptop simulations, designed to extend the readers' realizing of Aβ oligomerisation and fibril formation. even as, the publication delves into the pathogenesis of familial and sporadic Alzheimer's disorder on the atomic point of detail.
Written by means of prime authors of their respective fields, this booklet may be worthy to all scientists engaged on Alzheimer's disease.
Readership: common public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's ailment, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, buildings, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse versions, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
Read Online or Download Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) PDF
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Additional resources for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)
Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) by Philippe Derreumaux